乙酰胆碱受体（nAChR）单克隆抗体-mAb35

Immunogen

nicotinic acetylcholine receptor from the electric eel Electrophorus.

Legal Information

Sold with permission of the Salk Institute

Specificity

Binds to the main immunogenic region on the extracellular surface of the α₁ subunit of muscle AChR′s and to homologous regions on α₃ and α₅ subunits of neuronal AChR′s. The epitope is located on the extracellular surface of the α₁ subunit of the muscle nicotinic acetylcholine receptor. The antibody binds to denatured chick α₅ AChR, but does not bind well to denatured α₃, α₄, α₇, α_8, and β₂. It may also bind β₃ due to homology of main immunogenic region. May be used to localize and detect the α₁, α₃ and α₅ subunits of the nicotinic acetylcholine receptor (AChR).

Physical form

Solution in 20 mM Na₃PO₄, pH 7.2, containing 150 mM NaCl and 0.05 % sodium azide.