sAPP-beta Swedish Type

产品名称：sAPP-beta Swedish Type
产    地：Demeditec 
产品货号：JP27733
产品规格：96 Tests
产品说明：
Special remarks: Cross reactivity with sAPP beta Wild Type 0.11%, with sAPP-alpha <0.1%. This kit aso can be used for the investigation of brain tissue extract of Tg 2576 transgenic mice.
Alzheimer’s disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1906 and is considered as a major factor of dementia.  It is known that Amyloid beta (A-beta; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by beta-secretase and subsequent gamma-secretase. The production of soluble APP-beta (sAPP-beta) by beta-secretase cleavage corresponds to A-beta production accordingly, so it is desired to measure sAPP-beta in parallel with A-beta. In addition, it is reported that APP gene mutation exists in early-onset familial Alzheimer's disease patient.  Swedish mutation, one of the APP gene mutations, is a double mutation at positions -1 to -2 from the beta-secretase cleavage site (Lys670 --> Asn and Met671 --> Leu).  And further, it is reported that Swedish mutation elevates A-beta 40 and A-beta 42 production, and that the mutation is utilized in establishment of transgenic mice.  The measuring sAPP in Swedish type is useful for research of AD as well as in Wild type.
On the one hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by alpha-secretase rather than beta-secretase normally to produce soluble APP-alpha and subsequently P3 is cleaved from the remaining C-terminal fragment by gamma-secretase.  In recent research, there are several attempt to apply the inhibitor of beta-secretase and the activation of alpha-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPP-alpha as well as sAPP-beta (Wild Type, Swedish Type).  This kit can measure sAPP-beta Swedish Type.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!