GIP ELISA

产品名称：GIP ELISA
产    地：Demeditec 
产品货号：JP27201
产品规格：96 Tests
产品说明：
Special remarks:
INTENDED USE
For research use only, not for use in diagnostic procedures.
This IBL’s assay kit is capable for the quantitative determination active form human GIP in EDTA-plasma.
DPP-IV inhibitor has to be added when collecting samples, or use purpose-made blood collection tubes in order to preserve GIP.
INTRODUCTION
Incretins are a group of gastrointestinal hormones that cause an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating and they also inhibit glucagon release from the alpha cells of the Islets of Langerhans.
GIP, typical incretin like GLP-1, was isolated and sequenced from intestinal mucosa as “gastric inhibitory peptide” in 1970, and then it was renamed as “glucose-dependent insulinotropic peptide”. It has been reported that GIP receptor is expressed in cells such as beta cell of pancreas, adipocyte or osteoblastic cell, and it plays essential roles in reserving of ingested nutrients within the body in each cell, and the control of GIP signal can lead to improvement of metabolic syndrome.
It is rapidly inactivated to GIP (3-42) from active form of GIP (1-42) by DPP-IV in blood.
This ELISA kit can measure only active form of Human GIP (1-42).
PRINCIPLE
This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies. Tetra Methyl Benzidine (TMB) is used as a coloring agent (Chromogen). The strength of coloring is proportional to the quantities of active form human GIP.
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