Osteopontin human ELISA

产品名称：Osteopontin human ELISA
产    地：Demeditec 
产品货号：JP27158
产品规格：96 Tests
产品说明：
Special remarks: All samples have to be stored at -80°C as OPN is very unstable. The test system cross reacts with mouse OPN only 0.2%. With rat OPN there is no measurable cross reactivity.
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone.  At present, it is known as a highly acidic calcium-binding glycosylated phosphoprotein secreted by many cell types, including osteoblasts, kidney tubule cells, macrophages, activated T cells, and vascular smooth muscle cells. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation.
One important feature of OPN is that it contains an Arg-Gly-Asp (RGD) amino acid sequence.  This motif is present in fibronectin, vitronectin and a variety of other extra cellular proteins that bind members of the integrin family of cell surface receptors such as alpha v beta 3.
Another important of OPN is is the presence of various molecular forms in vivo due to differential RNA splicing, glycosylation, phosphorylation, sulfation, and susceptibility to proteases. Both OPN and thrombin are likely to be localized together at the site of injury, in- flammation, and angiogenesis and in tumor tissues. Osteopontin is susceptible to proteolytic fragmentation, and this process may have physiologic importance. A report demonstrated that thrombin treatment enhanced OPN cell adhesive activity, suggesting that cleavage of OPN by thrombin exposes a cryptic adhesive sequence. More recently, it was shown that an aminoterminal OPN fragment contains a cryptic binding site that can be recognized by alpha9beta1 integrin. Furthermore, OPN contains multiple cell binding sites and interacts with various receptors; these interactions may have distinct functional.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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