17OH-Progesterone free in saliva

产品名称：17OH-Progesterone free in saliva
产    地：Demeditec 
产品货号：DESLV3140
产品规格：96 Tests
产品说明：
Special remarks: In order to avoid arbitrary results we highly are recommending to always take 5 samples during a 2 hour period and measure the average value of the mixture.
We are highly recommending to only use appropriate validated sampling devices like the ones from Demeditec Diagnostics (see Saliva Set in this catalogue).
We also are supplying special devices for saliva sampling in newborns and handicapped patients. These are small soft plastic Pasteur pipettes. Please contact us for details.
17alpha-Hydroxyprogesterone (17OHP) is a 21-carbon steroid produced by adrenals, ovaries, testes and placenta. 17OHP is the metabolite of progesterone and 17-hydroxyprognenolone, and is a precursor to cortisol. Serum levels are primarily used to diagnose congenital adrenal hyperplasia (CAH). Deficiency of 21-hydroxylase blocks synthesis of cortisol, resulting in an increase of serum 17OHP levels, which leads to increase in ACTH secretion. Besides the classical CAH, late-onset and milder heterozygous forms of CAH also occur. They may clinically manifest themselves during the peripubertal period in the form of menstrual disturbances and hirsutism. Even in *****hood, hirsutism can signal the possible presence of a heterozygous form of CAH. Measurements of basal and post-ACTH stimulation 17OHP levels are helpful in the differential diagnosis of these conditions.
The measurement of 17OHP in serum or plasma samples from babies or young children is difficult because the high concentrations of conjugates present in blood. Therefore such serum and plasma samples should be extracted prior to the assay. The importance of the extraction step increases with decreasing age of the patient. In saliva the interference with the conjugates is not relevant at all, as conjugates are not present in saliva. Therefore salivary measurements of 17OHP even in newborns can be done without extraction step! This is not possible in serum or plasma samples.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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