8OHdG in saliva ELISA

产品名称：8OHdG in saliva ELISA
产    地：Demeditec 
产品货号：DEKOG200SE
产品规格：96 Tests
产品说明：
Special remarks: Thge assay system is a competitive binding assay using plates which are pre-coated with 8OHdG. The monoclonal antibody is supplied in liquid form. Therefore higher concentrations of 8OHdG will result in a lower signal at the end of the assay procedure.
Salivary 8OHdG seems to be a useful marker for oxidative damage of DNA or oxydative stress in total. Oxidative stress is a major cause of endothelial dysfunction. Oxidative stress produces reactive oxygen species, mainly superoxide, and may promote endothelial dysfunction by inactivating the production of NO. Oxidative stress might play a significant role in the pathophysiologic mechanism of erectile dysfunction.
There is some evidence that the measurement of salivary 8OHdG also is a useful biomarker for predicting severe erectile dysfunction and hypogonadism.
This recently has been published by Yasuda et al in the Journal of Sexual Medicine 2008 (online publication in February 2008).
The title of this paper is: Salivary 8-OHdG: A useful biomarker for predicting severe erectile dysfunction and hypogonadism.
Summary: Salivary 8-OHdG is a useful biomarker for predicting severe ED and hypogonadism in middle-aged men. Once-a-week treatment with Sildenafil can have benefical effects on men’s health by decreasing oxidative stress and increasing testosterone levels in serum and saliva.
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