Estrone RIA

产品名称：Estrone RIA
产    地：Demeditec 
产品货号：DEKIPI9100
产品规格：96 Tests
产品说明：
Special remarks:
1.INTENDED  USE
For  IN  VITRO  determination  of  serum  or   plasma ESTRONE levels.
The  origin  of  plama  estrogens  in  the  femal  have  been  precisely  studied  by refined isotopic dilution techniques.
In normal women, most plasma estradiol is derived from the ovary, where theca cells secrete androstenedione, which is then converted to estrone and then to estradiol by the granulosa cells.
Little estrone is indeed formed and secreted by the ovary : most originates from a   peripheral   conversion   of   estradiol   and   from   the   aromatisation   of androstenedione,  a  catalytic  reaction  essentially  carried  out  in  adipose tissue.
In  premenopausal  women,  androstenedione  is  secreted  by  the  ovary  and the adrenals.    In  pregnant  women,  the  fetal  adrenal  gland  provides  a significant contribution to androstenedione production.  In menopausal women, estrone is the essential estrogen found in the circulation, resulting from the conversion of adrenal androstenedione.  An increase in estrogen formation occurs with aging and in correlation with the amount of adipose tissue.  The estrogenic effects of estrone  in  menopausal  women  can  produce endometrial  hyperplasia  and bleeding  but  also  maintains  the  bone  mineral  content. In  premenopausal women, excessive estrone blood levels can result from the conversion of large amounts of androstenedione produced in micropolycystic ovary syndrome and ovarian tumors.  In such women, high estrone blood levels can participate in a disturbance of the menstrual cycle.
Estrone in the circulation is essentially bound to albumin.  This is important in the interpretation of estrone-assay data.  Indeed, and contrary to estradiol, total estrone levels are not significantly modified by SHBG concentration.
2.PRINCIPLE OF THE METHOD
Since  the  concentrations  of 125I  -  E1  and  coated  antibodies  are  constant,  the advancing  state  of  the  equation  depends  on  the  concentration  of  E1.    The amount  of 125I  -  E1  bound  to  the  coated  tube  is  inversely  proportional  to  the concentration of E1 in the sample. Following  the  incubation,  the  tube  is  washed  to  remove  excess  of  unbound labelled. Patient samples concentration are read from a calibration curve.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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