293/hTLR3

产品名称：293/hTLR3
规格：5-7 x 10e6 cells
货号：293-htlr3
厂商：invivogen
产品介绍:
Antibiotic resistance: blasticidin
Growth medium: DMEM, 4.5 g/l glucose, 2-4 mM L-glutamine, 10% (v/v) fetal bovine serum, 50 U/ml penicillin, 50 μg/ml streptomycin, 100 μg/ml Normocin™
Guaranteed mycoplasma-free
Shipped on dry ice
293/TLR3 cells were obtained by stable transfection of HEK293 cells with a pUNO-TLR3 plasmid which expresses the human or murine TLR3 gene.
The control cell line of 293/TLR3 cells is 293/null.
TLR3 recognizes double-stranded RNA (dsRNA), a molecular pattern associated with viral infection. Stimulation with poly(I:C), a synthetic analog of dsRNA, was shown to induce hyporesponsiveness in TLR3-deficient mice and considerable responsiveness in HEK293 cells expressing TLR3 [1], suggesting a specific recognition to poly(I:C) by TLR3. TLR3 signals mainly through a MyD88-independent pathway involving the TRIF/TICAM1 adapter protein that leads to the production of IFN-ß and causes dendritic cells to mature [2].

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