Astemizole **

产品名称：Astemizole
产品货号：Affix  AF3060
产品规格：50 mg
Technical Data
Chemical Name 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
Biological Description Astemizole is a potent histamine H 1 antagonist (IC 50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. potent hERG K + channel blocker (IC 50 = 0.9 nM) that displays cardiotoxicity in vivo.
Molecular Weight 458.5 daltons
Molecular Formula C28H31FN4O
Solubility Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) and chloroform
Purity >98%
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No. 68844-77-9
References Chong, C.R., et al. 2006. Nat. Chem. Biol. 2: 415-416.Wang, L., et al. 2009. Mol. Pharmacol. 75: 927-937.

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