Imatinib Mesylate

产品名称：Imatinib Mesylate
产品货号：Affix  AF3035
产品规格：100 mg
Technical Data
Chemical Name 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate
Biological Description Imatinib Mesylate is a multitargeted c-kit, PDGF-R and c-ABL inhibitor with IC50 of 3.9 and 2.9 μM for the inhibition of T-cell proliferation stimulated by DCs and PHA, respectively. A small molecule inhibitor of the Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). Imatinib Mesylate is a translocation event between chromosomes 9 and 22 generates thePhiladelphiachromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib binds up this crucial kinase, halting CML related growth.
Molecular Weight 589.7 daltons.
Molecular Formula C29H31N7O ·CH3SO3H
Solubility Soluble in water (200 mg/ml) and DMSO (100 mg/ml) Not soluble in methanol and ethanol.
Purity >98%
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No.  220127-57-1 
References Boucher, P., et al. 2003. Science. 300: 329-332

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