Gefitinib **

产品名称：Gefitinib
产品货号：Affix  AF3034
产品规格：100 mg
Technical Data
Chemical Name N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Biological Description Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. The  Gefitinib selective inhibitor of EGFR tyrosine kinase (IC50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice.
Molecular Weight 446.9 daltons.
Molecular Formula C22H24CIFN4O3
Solubility Soluble in DMSO, up to about (100 mg/mL) Not soluble in water or ethanol.
Purity >98%
Storage instructions Up to one week at 4°C or six months at -20°C.
CAS No. 184475-35-2 
References Lu, P.H., et al. 2010. Br J Dermatol.

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