Topiramate **

产品名称：Topiramate
产品货号：Affix  AF3017
产品规格：50 mg
Technical Data
Chemical Name 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Biological Description Topiramate is an Anticonvulsant. Antagonizes GluR5 kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Topiramate  is also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Molecular Weight 339.3 daltons
Molecular Formula C21H21NO8S
Solubility Soluble in DMSO (44 mg/ml) and in ethanol
Purity >98%
Storage instructions Store at -20°C
CAS No. 97240-79-4
References Ben-Menachem, E., Sander, J.W., Stefan, H., et al. Topiramate monotherapy in the treatment of newly or recently diagnosed epilepsy. Clin Ther 30(7) 1180-1195 (2008).

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