Zotarolimus **

产品名称：Zotarolimus
产品货号：LC  Z-9040
产品规格：25 MG
Zotarolimus (also known as ABT-578) is an analogue of rapamycin (sirolimus) that was designed to have a shorter in vivo half-life than rapamycin.  Zotarolimus was found to be comparable in potency for inhibiting in vitro proliferation of both rat and human T cells and mechanistically similar to sirolimus in having high-affinity binding to the immunophilin FKBP12.  Chen, Y.W., et al.  "Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression."  J. Cardiovasc. Pharmacol. 49:  228-235 (2007).
In vitro, zotarolimus inhibited FKBP-12 binding (IC50 = 2.8 nM) and potently blocked smooth muscle cell (IC50 = 2.9 nM) and endothelial cell (IC50 = 2.6 nM) proliferation.  After 28 days, zotarolimus stents from domestic juvenile swine exhibited less area stenosis (22.4% vs. 35.7%), less neointimal area (1.69 vs. 2.78 mm2), less neointimal thickness (0.25 vs. 0.38 mm), and greater lumen area (6.07 vs. 5.02 mm2) when compared to phosphorylcholine-coated stents.  Garcia-Touchard, A., et al.  "Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks."  Eur. Heart J. 27:  988-993 (2006).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Disposal:  A

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