Tyrphostin AG 1478, Free Base **

产品名称：Tyrphostin AG 1478, Free Base
产品货号：LC  T-7310
产品规格：1 G
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM).  Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 µM).  Osherov, N. and Levitzki, A.  "Epidermal-growth-factor-dependent activation of the src-family kinases."  Eur. J. Biochem. 225:  1047-1053 (1994).  Levitzki, A. and Gazit, A.  "Tyrosine kinase inhibition:  an approach to drug development."  Science 267:  1782-1788 (1995).
Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner.  Choi, B.H., et al.  "Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor."  Am. J. Physiol. Cell Physiol. 282:  C1461-C1468 (2002).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 50 mg/mL; soluble in ethanol at 25 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Appearance:  White solid.  Disposal:  A

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