Stauprimide **

产品名称：Stauprimide
产品货号：LC  S-9344
产品规格：10 MG
Stauprimide increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs).  Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc.  Zhu, S., et al.  "A small molecule primes embryonic stem cells for differentiation."  Cell Stem Cell 4:  416-426 (2009).
Stauprimide interacts with NME2, a c-Myc-activating transcription factor that is highly expressed in ESCs.  Stauprimide treatment inhibits the nuclear localization of NME2 and downregulates c-Myc, enhances ESC exit from the pluripotent state and enables differentiation.  Zaret, K.  "Using Small Molecules to Great Effect in Stem Cell Differentiation."  Cell Stem Cell 4:  373-374 (2009).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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