Staurosporine, Free Base **

产品名称：Staurosporine, Free Base
产品货号：LC  S-9300
产品规格：10 MG
Staurosporine is a potent inhibitor of many, many kinases including protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM).  Matsumoto, H. and Sasaki, Y.  "Staurosporine, a protein kinase C inhibitor, interferes with proliferation of arterial smooth muscle cells."  Biochem. Biophys. Res. Commun. 158:  105-109 (1989).  Tamaoki, T., et al.  "Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase."  Biochem. Biophys. Res. Commun. 135:  397-402 (1986).
Staurosporine induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons.  Boix, J., et al.  "Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines."  Neuropharmacology 36:  811-821 (1997).  Wiesner, D.A. and Dawson, G.,  "Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway."  J. Neurochem. 66:  1418-1425 (1996).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 2.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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