SB 203580, Free Base **

产品名称：SB 203580, Free Base
产品货号：LC  S-3400
产品规格：100 MG
Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK.  This kinase is a homolog of MAP kinase.  Gallagher, T.F., et al.  "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis."  Bioorg. Med. Chem. Lett. 5:  1171-1176 (1995).  Cuenda, A., et al.  "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1."  FEBS Lett.. 364:  229-233 (1995).  Hazzalin, C.A., et al.  "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli."  Oncogene 15:  2321-2331 (1997).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 12.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Appearance:  white to off-white solid.  Disposal:  A

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