SB 202190, Free Base **

产品名称：SB 202190, Free Base
产品货号：LC  S-1700
产品规格：100 MG
SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo through competition with ATP.  Young, P.R., et al.  "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site."  J. Biol. Chem. 272:  12116-12121 (1997).
Induces apoptosis through activation of cysteine protease (CPP32)-like caspases .  Nemoto, S., et al.  "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase."  J Biol Chem. 273:  16415-16420 (1998).
Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes.  Manthey, C.L., et al.  "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes."  J. Leukoc. Biol. 64:  409-417 (1998).  Ma, P., et al.  "Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation."  J. Leukoc. Biol. 76:  278-287 (2004).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Disposal:  A

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