(R,S)-Rolipram **

产品名称：(R,S)-Rolipram
产品货号：LC  R-2020
产品规格：100 MG
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor.  PDE4 enzymes inactivate cyclic AMP (cAMP) via hydrolysis to 5'-AMP.
Rolipram has two enantiomeric forms, R(-) and S(+).  This product is the racemic mixture of the two enantiomers.
R-(-)-rolipram demonstrated a higher affinity for the PDE4 enzyme than S-(+)-rolipram, by about 8-fold in vitro and about 12- to 15-fold in vivo.  Parker, C.A., et al.  "Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4."  Synapse 55:  270-279 (2005).
Rolipram is able to reverse ischemia-reperfusion (I/R)-induced increased microvascular permeability through cAMP phosphodiesterase (PDE) isozyme-selective inhibition.  Barnard, J.W., et al.  "Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor."  J. Appl. Physiol. 77:  774-781 (1994).
Rolipram reduced the initial and late response to ovalbumin (OVA) in isolated strips of guinea-pig colonic smooth muscle.  For both responses, the (S)-isomer (EC50 = approximately 1.0 µM) was about 10 fold less potent than the (R)-isomer (EC50 = approximately 0.1 µM).  Grous, M. and Barnette, M.  "Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle."  Br. J. Pharmacol. 111:  259-263 (1994).
Rolipram suppressed cardiopulmonary bypass-induced systemic inflammatory response syndrome, probably through the regulation of proinflammatory mediators by inhibiting phosphodiesterase type 4.  Hamamoto, M., et al.  "Suppressive effect of phosphodiesterase type 4 inhibition on systemic inflammatory responses after cardiopulmonary bypass."  J. Artif. Organs 9:  144-148 (2006).
R6/2 mutant mice recapitulate human Huntington's disease in many ways.  Rolipram has a neuroprotective effect in these mice.  After treatment with rolipram, R6/2 mice survived longer and displayed less severe signs of neurological dysfunction.  DeMarch, Z., et al.  "Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease."  Neurobiol. Dis. 30:  375-387 (2008).
Dopamine plays an essential role in the regulation of motor and cognitive functions.  The effect of dopamine largely depends on the cAMP/PKA signaling cascade.  Rolipram shows utility in neuropsychiatric and neurodegenerative disorders, posisbly by affecting dopamine neurotransmission.  Nishi, A., et al.  "Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum."  J. Neurosci. 28:  10460-10471 (2008).
Another CAS number previously assigned to rolipram, namely 85416-74-6, has been deleted by CAS and is no longer in use.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Disposal:  A

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