Paclitaxel **

产品名称：Paclitaxel
产品货号：LC  P-9600
产品规格：1 G
Antitumor and antileukemic agent isolated from the bark of the yew tree, Taxus brevifolia.  Wani, M.C., et al.  "Plant antitumor agents.  VI.  The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia."   J. Am. Chem. Soc. 93:  2325-2327 (1971).  McGuire, W.P., et al.  "Taxol:  a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms"   Ann. Int. Med. 111:  273-279 (1989).
Binds to β-tubulin and promotes the assembly of microtubules that resist depolymerization preventing normal cell division.  Rowinsky, E.K., et al.  "Taxol:  a novel investigational antimicrotubule agent." J. Natl. Cancer Inst. 82:  1247-1259 (1990).  Parekh, H. and Simpkins, H.  "The transport and binding of taxol."   Gen. Pharmacol. 29:  167-172 (1997).  Jordan, A., et al.  "Tubulin as a target for anticancer drugs:  agents which interact with the mitotic spindle investigational antimicrotubule agent."   Med. Res. Rev. 18:  259-296 (1998).
Induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway that results in Bcl-2 phosphorylation.  Wang, T.H., et al.  "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells."   J. Biol. Chem. 274:  8208-8216 (1999).  Shtil, A.A., et al.  "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells."   Oncogene 18:  377-384 (1999).  Srivastava, R.K., et al.  "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase."   Mol. Cell. Biol. 18:  3509-3517 (1998).  Torres, K., and Horwitz, S.B.  "Mechanisms of Taxol-induced cell death are concentration dependent."   Cancer Res. 58:  3620-3626 (1998).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 200 mg/mL; soluble in ethanol at 40 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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