PD 98059 **

产品名称：PD 98059, >99%
产品货号：LC  P-4313
产品规格：100 MG
Potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase).  Inhibits phosphorylation of MAP kinase by MAP kinase kinase.  PD 98059 does not inhibit MAP kinase itself.  IC50 values for PD 98059-induced effects are in the 1-20 µM range for many assays; it is somewhat weaker in inhibiting cell growth in monolayers or agar for some cell lines.  Dudley, D.T., et al.  "A synthetic inhibitor of the mitogen-activated protein kinase cascade."   "Proc. Natl. Acad. Sci. USA 92:  7686-7689 (1995).  Pang, L., et al.  "Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor."  J. Biol. Chem. 270:  13585-13588 (1995).  Waters, S.B., et al.  "Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex."  J. Biol. Chem. 270:  20883-20886 (1995).  Langlois, W.J., et al.  "Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation."  J. Biol. Chem. 270:  25320-25323 (1995).  Alessi, D.R., et al. "PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo."  J. Biol. Chem. 270:  27489-27494 (1995).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 25 mg/mL; soluble in ethanol at 1 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Appearance:   Pale-yellow powder  Disposal:  A

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