Lapatinib, Free Base **

产品名称：Lapatinib, Free Base
产品货号：LC  L-4899 
产品规格：1 G
This is the free base form of lapatinib; please see our product Lapatinib, Di-p-Toluenesulfonate Salt, Cat. No. L-4804, for further technical information.  The di-p-toluenesulfonate salt form of lapatinib, not the free base, is used in the lapatinib formulation for use in humans.
Lapatinib (as the di-p-toluenesulfonate salt) is the active ingredient in the drug sold under the trade names Tykerb® in the US and Tyverb® in Europe.  This drug has been approved in at least one country to treat advanced metastatic breast cancer in conjunction with the chemotherapy drug Xeloda (generic name, capecitabine).
The CAS number for Lapatinib, Free Base is given above.  The CAS number of the di-p-toluenesulfonate salt (Cat. No. L-4804) is 388082-77-7.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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