Ingenol 3-Angelate **

产品名称：Ingenol 3-Angelate
产品货号：LC  I-5900 
产品规格：5 MG
Protein Kinase C activator; anti-cancer drug.  Hampson, P., et al.  "PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC."  Blood 106:  1362-1368 (2005).  Kedei, N., et al.  "Characterization of the interaction of ingenol 3-angelate with protein kinase C."  Cancer Res. 64:  3243-3255 (2004).
Treatment with acids or bases or heating may cause rearrangement of the angeloyl group to the 5- or 20-positions leading to a significant decrease in potency.
SPECIAL HAZARD:  TUMOR PROMOTER.  Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO or ethanol.  Disposal:  A

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