Erlotinib, Free Base **

产品名称：Erlotinib, Free Base
产品货号：LC  E-4997  
产品规格：10 G
This is the free base form of erlotinib; please see our product Erlotinib, Hydrochloride Salt, Cat. No. E-4007, for further technical information.  The hydrochloride salt form of erlotinib, not the free base, is used in the erlotinib formulation for use in humans.
Erlotinib (as the hydrochloride salt) is the active ingredient in the drug product sold under the trade name Tarceva®.  This drug has been approved in at least one country for use in patients with pancreatic cancer, non-small cell lung cancer and several other types of cancer.  NOTE:  THE ERLOTINIB, FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT TARCEVA®, AND IS NOT FOR HUMAN USE.
This erlotinib product is the free base, whose CAS number is given above.  The CAS number of the hydrochloride salt is 183319-69-9.
Related CAS numbers:  248594-19-6 for the erlotinib mesylate.
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
Not available in some countries; not available to some institutions; not available for some uses.
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 10 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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