17-DMAG, Hydrochloride Salt **

产品名称：17-DMAG, Hydrochloride Salt
产品货号：LC  D-3440
产品规格：1 G
Synthetic derivative of geldanamycin, Cat. No. G-4500, and water-soluble analog of 17-AAG, Cat. No. A-6880, demonstrating stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG.  Egorin, M.J., et al.  "Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats."  Cancer Chemother. Pharmacol. 49:  7-19 (2002).
Binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin.  Tian, Z.Q., et al.  "Synthesis and biological activities of novel 17-aminogeldanamycin derivatives."  Bioorg. Med. Chem. 12:  5317-5329 (2004).
Inhibits angiogenesis.  Kaur, G, et al.  "Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator."  Clin. Cancer Res. 10:  4813-4821 (2004).
Enhances the radiation-induced cell cycle arrest of human solid tumor cell lines both in vitro and in vivo.  Bull, E.E., et al.  "Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin."  Clin. Cancer Res. 10:  8077-8084 (2004).
Exhibits potent anti-tumor activity against MDA-MB-231 breast carcinoma cells and HL60-TB leukemia cells both of which are relatively insensitive to 17-AAG.  Hollingshead, M., et al.  "In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative."  Cancer Chemother. Pharmacol. 56:  115-125 (2005).
Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO; soluble up to about 2 mg/mL in water.  Disposal:  A

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