Cyclopamine, Free Base **

产品名称：Cyclopamine, Free Base
产品货号：LC  C-8700 
产品规格：100 MG
Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins.  Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle.  Taipale, J., et al.  "Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine."  Nature 406:  944-945 (2000).  Chen, J.K., et al.  "Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened."  Genes & Dev. 16:  2743-2748 (2002).
SPECIAL HAZARD:  TERATOGEN.  Gloves and mask should be worn when using this compound.  Care must be taken to prevent contact through all routes of exposure.  Women of childbearing age should be extremely careful in handling cyclopamine!
Storage:  Store at or below -20 ºC.  Solubility:  See below.  Disposal:  A

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