Irinotecan HCl trihydrate **

产品名称：Irinotecan HCl trihydrate
产品货号：LKT  I6933
产品规格：10mg 
Description
Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.
Specifications 
Cas No. 136572-09-3
Product ID  I6933
Product Name  Irinotecan HCl trihydrate
Chemical Name  [1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
Synonym Irinotecan hydrochloride trihydrate; Camptosar; Campto
Formula Wt. 677.19
Melting Point 256.5oC
Purity ≥98% 
Solubility Slightly soluble in water, ethanol, chloroform.
Store Temp Ambient
References Kellner U, Rudolph P, Parwaresch R. Onkologie. 23:424-430 (2000). Kalemkerian GP, Worden FP. Expert Opin Investing Drugs. 9:565-79 (2000). Saltz LB. Curr Oncol Rep. 1:155-160 (1999).

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!