CD22 PerCP-eFluor 710 s-HCL-1, ASR, **

产品名称：CD22 PerCP-eFluor 710 s-HCL-1, ASR, 120 tests
产品货号：eBioscience 8046-4229-120
产品规格：120 tests
CD22 PerCP-eFluor® 710
Also known as: Siglec-2
Clone: S-HCL-1
Analyte Specific Reagent (ASR): Analytical and performance characteristics are not established.
SKU# 8046-4229
Cat. No. Size
8046-4229-025  25 tests 
8046-4229-120  120 tests 
Description: The S-HCl-1 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22 alpha and CD22 beta, 130 and 140 kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs (ITAM), which are phosphorylated upon B-cell receptor engagement and enable CD22 to participate in the positive and negative regulation of B-cell receptor signaling.

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