Anti-Glial Fibrillary Acidic Protein (GFAP) Alexa Fluor® 488 (GA5)**

产品名称：Anti-Glial Fibrillary Acidic Protein (GFAP) Alexa Fluor® 488 (GA5) 100 ug
产品货号：eBioscience 53-9892-82
产品规格：100 ug
Anti-Glial Fibrillary Acidic Protein (GFAP) Alexa Fluor® 488
Clone: GA5 (GA-5, G-A-5)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 53-9892
Cat. No. Size
53-9892-80  25 ug 
53-9892-82  100 ug 
Description: This GA5 monoclonal antibody reacts with human, mouse, rat, chicken, rabbit, and pig glial fibrillary acidic protein (GFAP). This 49-kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. Three alternative splice variants of GFAP exist; however, α-GFAP is the predominant form expressed in astrocytes. GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. Like other intermediate filaments, GFAP assembly is dependent on phosphorylation and dephosphorylation of the N-terminal domain. Studies have demonstrated that mutations in the GFAP gene lead to Alexander disease. Moreover, GFAP has also been shown to be overexpressed in certain glial-derived tumors.
 

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