Anti-Human/Mouse High Endothelial Venule Marker Alexa Fluor® 488 (MECA-79)

产品名称：Anti-Human/Mouse High Endothelial Venule Marker Alexa Fluor® 488 (MECA-79) 100 ug
产品货号：eBioscience 53-6036-82
产品规格：100 ug
Anti-Human/Mouse High Endothelial Venule Marker Alexa Fluor® 488
Also known as: HEV, PNAd, MECA-79
Clone: MECA-79
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 53-6036
Cat. No. Size
53-6036-80  25 ug 
53-6036-82  100 ug 
Description: This MECA-79 monoclonal antibody recognizes a sulfated carbohydrate epitope present on human and mouse high endothelial venules (HEVs) called peripheral lymph node addressin (PNAd). This glycoprotein is expressed on the luminal surface and in the cytoplasm of HEVs in lymphoid tissues, including peripheral and mesenteric lymph nodes and, to a lesser extent, Peyer’s patches. The MECA-79 antigen has also been detected on follicular B cells in the spleen and appendix in humans, as well as at sites of chronic inflammation. Post-capillary venules or large vessels in the spleen, thymus, or non-lymphoid tissues do not express the MECA-79 antigen and thus cannot be detected with this antibody. This addressin is involved in lymphocyte infiltration and adhesion into secondary lymphoid tissues.
The MECA-79 antibody has been reported to inhibit CD62L (L-selectin)-dependent lymphocyte emigration to HEVs and adhesion in lymph nodes and tonsils.

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