Alexa647 Mouse IL-21 (clone mhalx21), **

产品名称：Alexa647 Mouse IL-21 (clone mhalx21), 25 ug
产品货号：eBioscience 51-7213-80
产品规格：25 ug
Anti-Mouse IL-21 Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-7213)
Also known as: Interleukin-21
Clone: mhalx21
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 51-7213
Cat. No. Size
51-7213-80  25 ug 
Description: The monoclonal antibody mhalx21 reacts with mouse interleukin-21 (IL-21). IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by NKT, T helper (Th) 17 and T follicular helper (Tfh) cells. In Tfh cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1, IL-4 for Th2 and IL-17A for Th17, IL-21 is critical for Tfh cell effector function. This cytokine plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naïve B cells.
In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. High levels of IL-21 are present in chemically-induced colitis models. IL-21-deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules.
Preliminary data suggest that clone mhalx21 recognizes a different epitope than anti-mouse IL-21 clone FFA21 (cat. 51-7211).

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