Human Act1 (clone 9ACT12), **

产品名称：Human Act1 (clone 9ACT12), 100 tests
产品货号：eBioscience 51-4040-42
产品规格：100 tests
Anti-Human ACT1 Alexa Fluor® 647
Also known as: Nuclear Factor kappa B Activator 1, TRAF3 interacting protein 2, TRAF3IP2, CIKS
Clone: 9ACT12
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 51-4040
Cat. No. Size
51-4040-41  25 tests 
51-4040-42  100 tests 
Description: The monoclonal antibody 9ACT12 reacts with human Act1 (NF-κB activator 1), also known as CIKS (a connection to IkB kinase and stress-activated kinase). Originally cloned for its ability to activate NF-κB and its direct interaction with IKKγ, Act1 has been subsequently shown to play several roles in immunity. In B cells, it is a negative regulator of CD40 and BAFFR signaling affecting reduced survival. This regulation is through direct interaction of Act1 with CD40 or BAFFR and TRAF3. In addition, Act1 is involved in IL-17R signaling. It interacts with IL-17RA through the homotypic SEFIR interaction domain and is critical for downstream NF-κB- and C/EBP-mediated inflammatory responses.

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