Anti-Human CD42a eFluor® 450 (GR-P) **

产品名称：Anti-Human CD42a eFluor® 450 (GR-P) 100 tests
产品货号：eBioscience 48-0428-42
产品规格：100 tests
Anti-Human CD42a eFluor® 450
Also known as: Glycoprotein IX, GP9
Clone: GR-P
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 48-0428
Cat. No. Size
48-0428-41  25 tests 
48-0428-42  100 tests 
Description: This GR-P monoclonal antibody reacts with human CD42a, which is also known as glycoprotein IX (GPIX). CD42a is a 22-kDa transmembrane protein that is constitutively expressed on platelets and megakaryocytes. CD42a associates with CD42b, CD42c, and CD42d to form the GPIb-V-IX complex, which binds the von Willebrand factor, an endothelial adhesion protein, to mediate platelet adhesion and activation. This binding results in platelet aggregation at sites of vascular injury. This receptor complex has also been demonstrated to bind thrombin, factors XI and XII, P-selectin, and Mac-1. Finally, a point mutation within the leucine-rich motif of CD42a has been linked to Bernard-Soulier syndrome.

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