eFluorTM 450 anti-mouse CD41 (fibrinogen receptor, gpIIb/IIIa, integrin alpha I

产品名称：eFluorTM 450 anti-mouse CD41 (fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb) 100 ug
产品货号：eBioscience 48-0411-82
产品规格：100 tests
Anti-Mouse CD41 eFluor® 450
Also known as: fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib, ITGA2b
Clone: eBioMWReg30 (MWReg30)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 48-0411
Cat. No. Size
48-0411-80  25 ug 
48-0411-82  100 ug 
Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and *****. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.
Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

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