Anti-Mouse LAP (Latency Associated Peptide) (TW7-16B4) PerCP-eFluor® 710,

产品名称：Anti-Mouse LAP (Latency Associated Peptide) (TW7-16B4) PerCP-eFluor® 710, 100 ug
产品货号：eBioscience 46-9821-82
产品规格：100 ug
Anti-Mouse LAP (Latency Associated Peptide) PerCP-eFluor® 710
Also known as: Pro-TGF beta 1, LAP/TGF beta 1
Clone: TW7-16B4
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 46-9821
Cat. No. Size
46-9821-80  25 ug 
46-9821-82  100 ug 
Description: The TW7-16B4 monoclonal antibody reacts with mouse latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.

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