Mouse Ly49G2 (clone eBio4D11), **

产品名称：Mouse Ly49G2 (clone eBio4D11), 100 ug
产品货号：eBioscience 46-5781-82
产品规格：100 ug
Anti-Mouse Ly-49G2 PerCP-eFluor® 710
Also known as: LGL-1, Ly49G2, Ly49
Clone: eBio4D11 (4D11)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 46-5781
Cat. No. Size
46-5781-80  25 ug 
46-5781-82  100 ug 
Description: The 4D11 monoclonal antibody reacts with Ly-49G2 (also known as LGL-1). The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate recognition domains, which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor. Ly-49G2 is an inhibitory receptor expressed on subsets of natural killer (NK) cells, NK-T cells (in all strains tested), and on a population of memory CD8+ T cells (in C57BL/6 mice). The 4D11 antibody has been reported to cross react with the Ly-49AB6, Ly-49ABALB, and Ly-49T129/J inhibitory receptors and Ly-49LCBA/J activatingreceptors. The proportion of NK-T cells expressing Ly-49A and Ly-49G2 is higher in the thymus than in liver, and there is evidence that down-regulation of Ly-49 receptor expression is necessary for normal NK–T-cell development to occur.

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