Anti-Human CD114 (G-CSFR) (clone LMM741) PerCP-eFluor 710,**

产品名称：Anti-Human CD114 (G-CSFR) (clone LMM741) PerCP-eFluor 710, 100 tests
产品货号：eBioscience 46-1149-42
产品规格：100 tests
Anti-Human CD114 (G-CSFR) PerCP-eFluor® 710
Also known as: Granulocyte colony-stimulating factor receptor, CSF3R
Clone: LMM741
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 46-1149
Cat. No. Size
46-1149-41  25 tests 
46-1149-42  100 tests 
Description: This LMM741 monoclonal antibody reacts with human CD114, which is also known as granulocyte colony-stimulating factor receptor (G-CSFR). A type I hematopoietin cytokine receptor, CD114 is expressed on granulocytes such as neutrophils, myeloid cells, monocytes, and leukemic cells. This receptor is absent from lymphocytes, erythrocytes, and eosinophils. CD114 can also be detected on non-hematopoietic cells, including neurons, endothelial cells, and cardiomyocytes. Studies demonstrate that expression of CD114 can be downregulated by LPS, TNF, phorbol ester, and G-CSF itself. Binding of G-CSF binding induces homodimerization of the receptor that activates signaling transduction (e.g., the JAK/STAT and Erk1/2 pathways) to mediate cell proliferation, survival, and differentiation.

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