Anti-Human Syk APC (4D10.1) **

产品名称：Anti-Human Syk APC (4D10.1) 100 tests
产品规格：eBioscience 17-6696-42
产品货号：100 tests
Anti-Human Syk APC
Clone: 4D10.1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-6696
Cat. No. Size
17-6696-41  25 tests 
17-6696-42  100 tests 
Description: This 4D10.1 monoclonal antibody recognizes human Syk, a 72-kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.

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