Anti-Human CD243 (ABCB1) APC (UIC2) 原装**

产品名称：Anti-Human CD243 (ABCB1) APC (UIC2) 100 tests
产品规格：eBioscience 17-2439-42
产品货号：100 tests
Anti-Human CD243 (ABCB1) APC
Also known as: P-glycoprotein-1, MDR1
Clone: UIC2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-2439
Cat. No. Size
17-2439-41  25 tests 
17-2439-42  100 tests 
Description: This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170-kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.
This antibody has been reported to inhibit MDR1-mediated efflux.

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