APC Human CD172a (clone 15-414), **

产品名称：APC Human CD172a (clone 15-414), 100 tests
产品规格：eBioscience 17-1729-42
产品货号：100 tests
Anti-Human CD172a (SIRP alpha) APC
Also known as: SIRPa, SHPS-1
Clone: 15-414
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-1729
Cat. No. Size
17-1729-41  25 tests 
17-1729-42  100 tests 
Description: This 15-414 monoclonal antibody reacts with human CD172a, also known as signal regulatory protein alpha (SIRP alpha). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, granulocytes, dendritic cells, and CD34+CD38- hematopoietic progenitor cells but not on T and B lymphocytes. Moreover, neurons have also been shown to express CD172. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

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