Anti-Human CD61 (Integrin beta 3) APC (VI-PL2) **

产品名称：Anti-Human CD61 (Integrin beta 3) APC (VI-PL2) 100 tests
产品货号：eBioscience 17-0619-42
产品规格：100 tests
Anti-Human CD61 (Integrin beta 3) APC
Also known as: ITGB3
Clone: VI-PL2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-0619
Cat. No. Size
17-0619-41  25 tests 
17-0619-42  100 tests 
Description: The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.
This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.

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