APC Human CD47 (clone B6H12), **

产品名称：APC Human CD47 (clone B6H12), 100 tests
产品货号：eBioscience 17-0479-42
产品规格：100 tests
Anti-Human CD47 APC
Also known as: Integrin associated protein, IAP, neurophilin
Clone: B6H12
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-0479
Cat. No. Size
17-0479-41  25 tests 
17-0479-42  100 tests 
Description: The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 integrins CD51/CD61 and CD41/CD61. Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells.
This antibody has been reported to have neutralizing activity.

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