Functional Grade Mouse IL-21 (clone FFA21), **

产品名称：Functional Grade Mouse IL-21 (clone FFA21), 500 ug
产品货号：eBioscience 16-7211-85
产品规格：500 ug 
Anti-Mouse IL-21 Functional Grade Purified
Also known as: Interleukin-21
Clone: FFA21
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-7211
Cat. No. Size
16-7211-82  100 ug 
16-7211-85  500 ug 
Description: This FFA21 monoclonal antibody reacts with mouse interleukin-21 (IL-21) and can neutralize its bioactivity.
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by NKT, T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFNγ for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. This cytokine plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naïve B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and RORγt lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and RORγt, IL-21 also mediates the downregulation of Foxp3. High levels of IL-21 are present in chemically-induced colitis models. IL-21-deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules.

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