Anti-Mouse Delta-like 4 (clone HMD4-1) Functional Grade Purified, **

产品名称：Anti-Mouse Delta-like 4 (clone HMD4-1) Functional Grade Purified, 500 ug
产品货号：eBioscience 16-5948-85
产品规格：500 ug
Anti-Mouse Delta-like 4 Functional Grade Purified
Also known as: DLL4
Clone: HMD4-1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-5948
Cat. No. Size
16-5948-82  100 ug 
16-5948-85  500 ug 
Description: This HMD4-1 monoclonal antibody reacts with the extracellular domain of mouse Delta-like 4, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Delta-like 4 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Delta-like 4 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. This molecule is also expressed in non-immune cells, including vascular smooth muscle and endothelial cells. Delta-like 4 plays a role in T cell development, regulation of experimental autoimmune encephalomyelitis, and the formation of mature vasculature.
The HMD4-1 monoclonal antibody has been reported to have blocking activity and crossreact to rat.

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