Anti-Human CD85d (ILT4) Functional Grade Purified **

产品名称：Anti-Human CD85d (ILT4) Functional Grade Purified (27D6) 500 ug
产品货号：eBioscience 16-5148-85
产品规格：500 ug
Anti-Human CD85d (ILT4) Functional Grade Purified
Also known as: ILT-4, LIR2, LILRB2, MIR10
Clone: 27D6
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-5148
Cat. No. Size
16-5148-81  50 ug 
16-5148-85  500 ug 
Description: The monoclonal antibody 27D6 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leuokocyte Ig-like receptor) MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor containing 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection.
The monoclonal antibody 27D6 has been shown to block binding of ligand (HLA-G tetramer).

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