Anti-Human CD85j (ILT2) Functional Grade (HP-F1) **

产品名称：Anti-Human CD85j (ILT2) Functional Grade (HP-F1) 100 ug
产品货号：eBioscience 16-5129-82
产品规格：100 ug
Anti-Human CD85j (ILT2) Functional Grade Purified
Also known as: LIR1, LILRB1, MIR7
Clone: HP-F1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-5129
Cat. No. Size
16-5129-82  100 ug 
Description: The monoclonal antibody HP-F1 recognizes CD85j, also known as ILT2, LILRB1, and LIR1. CD85j is a member of the ILT (immunoglobulin-like transcript)/LIR (leukocyte Ig-like receptor)/MIR (monocyte Ig-like receptor) family. CD85j is a single transmembrane glycoprotein with a long cytoplasmic domain containing 4 ITIMs which signal through interactions with SHP-1. Expression is found on myeloid cells (monocytes and dendritic cells) and some lymphoid cells including, subsets of NK, T and B cells. Expression has been correlated with leukemias such as ALL and CLL. Expression on CD8+ cells correlates with effector cell function and plays an important role in viral infections, including HIV, Ebstein Barr and CMV. The ligands for CD85j are MHC Class I molecules such as HLA-G, A, F, B27, E and F.
The monoclonal antibody HP-F1 has been shown to reduce the amount of CD16- dependent cytolytic activity of functional NK cells.

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