Anti-CD324 (E-Cadherin) Functional Grade Purified (DECMA-1)**

产品名称：Anti-CD324 (E-Cadherin) Functional Grade Purified (DECMA-1) 500 ug
产品货号：eBioscience 16-3249-85
产品规格：500 ug
Anti-CD324 (E-Cadherin) Functional Grade Purified
Also known as: epithelial cadherin
Clone: DECMA-1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-3249
Cat. No. Size
16-3249-82  100 ug 
16-3249-85  500 ug 
Description: The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton. Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers.
E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided.
The monoclonal antibody DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!