anti-mouse CD180 FG Purified RP/14 **

产品名称：anti-mouse CD180 FG Purified RP/14 500 ug
产品货号：eBioscience 16-1801-85
产品规格：500 ug
Anti-Mouse CD180 (RP105) Functional Grade Purified
Also known as: RP-105, Toll-like Receptor, TLR Family, LY-78
Clone: RP/14
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-1801
Cat. No. Size
16-1801-81  50 ug 
16-1801-82  100 ug 
16-1801-85  500 ug 
Description: The RP/14 monoclonal antibody reacts with mouse CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on mature B cells, monocytes/macrophages and dendritic cells. Ligation of RP105 with RP/14 protects B cells from irradiation- or dexamethasone-induced apoptosis, and drives them to proliferate. B cells activated by RP105-ligation arrest their growth and undergo apoptosis when the antigen receptor is engaged. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death.

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