anti-mouse CD86 FG Purified PO3.1 **

产品名称：anti-mouse CD86 FG Purified PO3.1 1 mg
产品货号：eBioscience 16-0861-86
产品规格：1 mg
Anti-Mouse CD86 (B7-2) Functional Grade Purified
Also known as: B70, Ly-58
Clone: PO3.1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 16-0861
Cat. No. Size
16-0861-81  50 ug 
16-0861-82  100 ug 
16-0861-85  500 ug 
16-0861-86  1 mg 
Description: The PO3.1 monoclonal antibody reacts with mouse CD86, an ~80 kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.

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