Recombinant human TGFbeta3,**

产品名称：Recombinant human TGFbeta3, 25 ug
产品货号：eBioscience 14-8369-80
产品规格：25 ug
Human TGF beta 3 Recombinant Protein
Also known as: Transforming Growth Factor beta 3, TGF-beta3, TGFbeta3
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-8369
Cat. No. Size
14-8369-62  5 ug 
14-8369-80  25 ug 
Description: Transforming growth factor β3 (TGF-β3) is the third member of the transforming growth factor family of cytokines, which also includes TGF-β1 and -β2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF bet ;3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.
The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF-β cytokines, and indicates an important role in the protection against autoimmunity.

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